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Three years after initial diagnosis, left ventricular shortening fraction and left ventricular wall thickness were both significantly worse in patients who received doxorubicin alone than in patients who received dexrazoxane, indicating that dexrazoxane was cardioprotective.[7] With combined data from three COG trials that randomized dexrazoxane with doxorubicin therapy (P9404, P9425, and P9426) and had a median follow-up of 12.6 years, dexrazoxane did not appear to compromise long-term survival.[8][Level of evidence A1] On protocols of the former Children’s Cancer Group (CCG), children with T-ALL received the same treatment regimens as did children with B-ALL

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Processing, soil depletion, and lifestyle factors can reduce the nutritional value of foods